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GS-441524, GS441524, GS-441, GS441, Feline infectious peritonitis, FIP, treatment, tablet, capsule, injection

Efficacy and safety of the nucleoside analog GS-441524 for treatment of cats with naturally occurring feline infectious peritonitis

Abstract Objectives The aim of this study was to determine the safety and efficacy of the nucleoside analog GS-441524 for cats suffering from various forms of naturally acquired feline infectious peritonitis (FIP). Methods Cats ranged from 3.4–73 months of age (mean 13.6 months); 26 had effusive or dry-to-effusive FIP and five had non-effusive disease. Cats …

Efficacy and safety of the nucleoside analog GS-441524 for treatment of cats with naturally occurring feline infectious peritonitis Read More »

GS-441524, GS441524, GS-441, GS441, Feline infectious peritonitis, FIP, treatment, tablet, capsule, injection

Antiviral treatment using the adenosine nucleoside analogue GS-441524 in cats with clinically diagnosed neurological feline infectious peritonitis

Abstract Feline infectious peritonitis (FIP) is caused by a mutant biotype of the feline enteric coro- navirus. The resulting FIP virus (FIPV) commonly causes central nervous system (CNS) and ocular pathology in cases of noneffusive disease. Over 95% of cats with FIP will suc- cumb to disease in days to months after diagnosis despite a …

Antiviral treatment using the adenosine nucleoside analogue GS-441524 in cats with clinically diagnosed neurological feline infectious peritonitis Read More »

GS-441524, GS441524, GS-441, GS441, Feline infectious peritonitis, FIP, treatment, tablet, capsule, injection

The nucleoside analog GS-441524 strongly inhibits feline infectious peritonitis (FIP) virus in tissue culture and experimental cat infection studies

Abstract Feline infectious peritonitis (FIP) is a common and highly lethal coronavirus disease of domestic cats. Recent studies of diseases caused by several RNA viruses in people and other species indicate that antiviral therapy may be effective against FIP in cats. The small molecule nucleoside analog GS-441524 is a molecular precursor to a pharmacologically active …

The nucleoside analog GS-441524 strongly inhibits feline infectious peritonitis (FIP) virus in tissue culture and experimental cat infection studies Read More »

close up photo of yellow and white cat

Fifty years’ fascination with FIP culminates in a promising new antiviral

By Niels C Pedersen DVM, PhDCentre for Companion Animal Health, School of Veterinary Medicine, University of California, Davis, USA Feline infectious peritonitis (FIP) has been my fascina- tion for the past 50 years. Although caused by a virus, FIP most closely resembles mycobacterial infections that cause human and feline tuberculosis and leprosy. The disease has …

Fifty years’ fascination with FIP culminates in a promising new antiviral Read More »

GS-441524, GS441524, GS-441, GS441, Feline infectious peritonitis, FIP, treatment, tablet, capsule, injection

FIP Treatment from Dr. Niels Pedersen

By Dr. Niels Pedersen Symptomatic Treatment There is currently no effective treatment that is legally available for cats with confirmed FIP. Until new treatments can be approved and marketed, treatment remains largely symptomatic. A low to moderate dosage of prednisolone or prednisone (starting at 2 mg/kg, orally, once a day for two weeks and then …

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Niels C. Pedersen FIP Cat GS-441524

GS-441524 treatment & dosage

Treatment with oral formulations of GS-441524 Niels C. Pedersen, Nicole Jacque September 24, 2021 The initial field testing of GS-441524 for FIP treatment involved subcutaneous injection. This route of administration was based on prior pharmacokinetic (PK) studies done on laboratory cats. Intravenous and subcutaneous routes of injection yielded similar high blood levels that were sustained …

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Curing Cats with Feline Infectious Peritonitis with an Oral Multi-Component Drug Containing GS-441524

Abstract Feline infectious peritonitis (FIP) caused by feline coronavirus (FCoV) is a common dis-ease in cats, fatal if untreated, and no effective treatment is currently legally available. The aim of this study was to evaluate efficacy and toxicity of the multi-component drug Xraphconn® in vitro and as oral treatment in cats with spontaneous FIP by …

Curing Cats with Feline Infectious Peritonitis with an Oral Multi-Component Drug Containing GS-441524 Read More »

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