1. Hide the GS-441524 pills in food Giving GS-441524 pills to FIP cats can be a challenge, even for the most experienced veterinarian! The easiest way to give your cat a pill is to hide the pill in food. This usually works best if the pill is hidden in a small amount of wet cat …
How to inject GS-441524 Injecat The injections are given sub-cutaneously or “sub-cu” which means just under the skin. Injections are to be given every 24 hours at as close to the same time everyday as is possible for at least 12 weeks. The needle should NOT poke into the muscle of …
Abstract Objectives The aim of this study was to determine the safety and efficacy of the nucleoside analog GS-441524 for cats suffering from various forms of naturally acquired feline infectious peritonitis (FIP). Methods Cats ranged from 3.4–73 months of age (mean 13.6 months); 26 had effusive or dry-to-effusive FIP and five had non-effusive disease. Cats …
Abstract Feline infectious peritonitis (FIP) is caused by a mutant biotype of the feline enteric coro- navirus. The resulting FIP virus (FIPV) commonly causes central nervous system (CNS) and ocular pathology in cases of noneffusive disease. Over 95% of cats with FIP will suc- cumb to disease in days to months after diagnosis despite a …
Abstract Feline infectious peritonitis (FIP) is a common and highly lethal coronavirus disease of domestic cats. Recent studies of diseases caused by several RNA viruses in people and other species indicate that antiviral therapy may be effective against FIP in cats. The small molecule nucleoside analog GS-441524 is a molecular precursor to a pharmacologically active …
By Niels C Pedersen DVM, PhDCentre for Companion Animal Health, School of Veterinary Medicine, University of California, Davis, USA Feline infectious peritonitis (FIP) has been my fascina- tion for the past 50 years. Although caused by a virus, FIP most closely resembles mycobacterial infections that cause human and feline tuberculosis and leprosy. The disease has …
Fifty years’ fascination with FIP culminates in a promising new antiviral Read More »
By Dr. Niels Pedersen Symptomatic Treatment There is currently no effective treatment that is legally available for cats with confirmed FIP. Until new treatments can be approved and marketed, treatment remains largely symptomatic. A low to moderate dosage of prednisolone or prednisone (starting at 2 mg/kg, orally, once a day for two weeks and then …
Treatment with oral formulations of GS-441524 Niels C. Pedersen, Nicole Jacque September 24, 2021 The initial field testing of GS-441524 for FIP treatment involved subcutaneous injection. This route of administration was based on prior pharmacokinetic (PK) studies done on laboratory cats. Intravenous and subcutaneous routes of injection yielded similar high blood levels that were sustained …
Abstract Feline infectious peritonitis (FIP) caused by feline coronavirus (FCoV) is a common dis-ease in cats, fatal if untreated, and no effective treatment is currently legally available. The aim of this study was to evaluate efficacy and toxicity of the multi-component drug Xraphconn® in vitro and as oral treatment in cats with spontaneous FIP by …
1.What is Feline infectious peritonitis (FIP)? FCoV is a virus of the gastrointestinal tract. Most infections are either asymptomatic or cause diarrhea, especially in kittens, as maternally derived antibody wanes at between 5 and 7 weeks of age. The virus is a mutation of feline enteric coronavirus (FECV). From the gut, the virus very briefly …
